{"id":5206,"date":"2026-03-27T16:47:44","date_gmt":"2026-03-27T16:47:44","guid":{"rendered":"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/"},"modified":"2026-03-27T16:47:44","modified_gmt":"2026-03-27T16:47:44","slug":"astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed","status":"publish","type":"post","link":"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/","title":{"rendered":"AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div id=\"RegularArticle-ArticleBody-5\" data-module=\"ArticleBody\" data-test=\"articleBody-2\" data-analytics=\"RegularArticle-articleBody-5-2\"><span class=\"HighlightShare-hidden\" style=\"top:0;left:0\"\/><\/p>\n<div class=\"group\">\n<p><span class=\"QuoteInBody-quoteNameContainer\" data-test=\"QuoteInBody\" id=\"RegularArticle-QuoteInBody-1\"><a href=\"https:\/\/www.cnbc.com\/quotes\/AZN-GB\/\">AstraZeneca<\/a><span class=\"QuoteInBody-inlineButton\"><span class=\"AddToWatchlistButton-watchlistContainer\" id=\"-WatchlistDropdown\" data-analytics-id=\"-WatchlistDropdown\"><button class=\"AddToWatchlistButton-watchlistButton\" aria-label=\"Add To Watchlist\" data-testid=\"dropdown-btn\"><span class=\"AddToWatchlistButton-addWatchListFromTag\"\/><\/button><\/span><\/span><\/span>&#8216;s stock rose over 3% after Britain&#8217;s most valuable company said its experimental lung disease medicine met its target in two late-stage clinical trials. <\/p>\n<p>The respiratory treatment tozorakimab, reduced flare-ups of chronic obstructive pulmonary disease (COPD) in both former smokers and in the overall population versus placebo, the company said.<\/p>\n<p>&#8220;This marks a notable shift in sentiment, given limited conviction in the IL-33 mechanism following prior IL-33 failures from <span class=\"QuoteInBody-quoteNameContainer\" data-test=\"QuoteInBody\" id=\"RegularArticle-QuoteInBody-2\"><a href=\"https:\/\/www.cnbc.com\/quotes\/SAN-FR\/\">Sanofi<\/a><span class=\"QuoteInBody-inlineButton\"><span class=\"AddToWatchlistButton-watchlistContainer\" id=\"-WatchlistDropdown\" data-analytics-id=\"-WatchlistDropdown\"><button class=\"AddToWatchlistButton-watchlistButton\" aria-label=\"Add To Watchlist\" data-testid=\"dropdown-btn\"><span class=\"AddToWatchlistButton-addWatchListFromTag\"\/><\/button><\/span><\/span><\/span> and <span class=\"QuoteInBody-quoteNameContainer\" data-test=\"QuoteInBody\" id=\"RegularArticle-QuoteInBody-3\"><a href=\"https:\/\/www.cnbc.com\/quotes\/ROG-CH\/\">Roche<\/a><span class=\"QuoteInBody-inlineButton\"><span class=\"AddToWatchlistButton-watchlistContainer\" id=\"-WatchlistDropdown\" data-analytics-id=\"-WatchlistDropdown\"><button class=\"AddToWatchlistButton-watchlistButton\" aria-label=\"Add To Watchlist\" data-testid=\"dropdown-btn\"><span class=\"AddToWatchlistButton-addWatchListFromTag\"\/><\/button><\/span><\/span><\/span>,&#8221; said Jefferies analysts.<\/p>\n<p>Tozorakimab and rival drugs belong to a class of treatments called monoclonal antibodies. They work \u200bby suppressing the action \u2060of the protein interleukin-33 (IL-33) and can reduce inflammation.<\/p>\n<p>&#8220;Today&#8217;s tozorakimab results deliver the first two confirmatory Phase III trials for an IL-33 biologic, which is a major scientific advancement in COPD, the world&#8217;s third leading cause of death,&#8221; said Sharon Barr, executive vice president of biopharmaceuticals and R&amp;D at AstraZeneca. <\/p>\n<p>&#8220;Tozorakimab works in a fundamentally different way from other biologics, inhibiting the signalling of the reduced and oxidised forms of IL-33 to both decrease inflammation and disrupt the cycle of mucus dysfunction that are key disease drivers in COPD,&#8221; Barr said.<\/p>\n<p>The full results will be disclosed at an upcoming medical meeting, AstraZeneca said.<\/p>\n<p>In July, Swiss drugmaker Roche reported mixed results for its COPD drug astegolimab, which ultimately <a href=\"https:\/\/www.roche.com\/investors\/updates\/inv-update-2025-07-21\" target=\"_blank\">failed to reduce flare-ups\u00a0in a phase 3 study.<\/a> Similar to tozorakimab, it is designed to stop the binding of IL-33.<\/p>\n<p>Two months earlier, <a href=\"https:\/\/www.sanofi.com\/en\/media-room\/press-releases\/2025\/2025-05-30-05-00-00-3090818\" target=\"_blank\">France&#8217;s Sanofi had reported similarly mixed results<\/a> for its drug itepekimab which it is developing jointly with <span class=\"QuoteInBody-quoteNameContainer\" data-test=\"QuoteInBody\" id=\"RegularArticle-QuoteInBody-6\"><a href=\"https:\/\/www.cnbc.com\/quotes\/REGN\/\">Regeneron<\/a><span class=\"QuoteInBody-inlineButton\"><span class=\"AddToWatchlistButton-watchlistContainer\" id=\"-WatchlistDropdown\" data-analytics-id=\"-WatchlistDropdown\"><button class=\"AddToWatchlistButton-watchlistButton\" aria-label=\"Add To Watchlist\" data-testid=\"dropdown-btn\"><span class=\"AddToWatchlistButton-addWatchListFromTag\"\/><\/button><\/span><\/span><\/span>. <\/p>\n<p>AstraZeneca&#8217;s London-listed shares ended the session up 3.4%, contrasting with the UK&#8217;s <span class=\"QuoteInBody-quoteNameContainer\" data-test=\"QuoteInBody\" id=\"RegularArticle-QuoteInBody-7\"><a href=\"https:\/\/www.cnbc.com\/quotes\/.FTSE\/\">FTSE 100<\/a><span class=\"QuoteInBody-inlineButton\"><span class=\"AddToWatchlistButton-watchlistContainer\" id=\"-WatchlistDropdown\" data-analytics-id=\"-WatchlistDropdown\"><button class=\"AddToWatchlistButton-watchlistButton\" aria-label=\"Add To Watchlist\" data-testid=\"dropdown-btn\"><span class=\"AddToWatchlistButton-addWatchListFromTag\"\/><\/button><\/span><\/span><\/span> index which closed just below the flatline. Astra&#8217;s Friday update also lifted shares of Roche and Sanofi by around 1% each.<\/p>\n<\/div>\n<h2 class=\"ArticleBody-subtitle\"><a id=\"headline0\"\/>Multi-billion dollar potential<\/h2>\n<div class=\"group\">\n<p>Nearly 400 million people are diagnosed with COPD, and it&#8217;s one of the\u00a0leading causes of death worldwide, according to the World Health Organization.<\/p>\n<p>It&#8217;s a progressive respiratory condition that manifests through breathlessness, chronic cough, and excess mucus production. Symptoms can worsen over time and contribute to ongoing inflammation and bronchoconstriction, making it difficult to breathe and increasing the risk of COPD exacerbations.<\/p>\n<p>AstraZeneca has forecast tozorakimab peak annual sales of between $3 billion and $5 billion, whereas estimates on average put peak sales at about $1 billion prior to Friday&#8217;s trial results, according to FactSet.<\/p>\n<p>The trial results showed a benefit for both former and current smokers, across all lung\u2011function severities.<\/p>\n<p>It also indicated a benefit for patients with a low amount of a type of white blood cell called eosinophil, which is a key unmet need for about 35% of patients, Citi analysts noted. <\/p>\n<p>Tozorakimab is also being studied in a Phase 3 trial for severe viral lower respiratory tract disease and in a Phase 2 trial in asthma.<\/p>\n<p>Astra is planning to launch more than 20 new drugs over the next five years and has targeted $80 \u2060billion in annual sales by 2030.<\/p>\n<\/div>\n<div class=\"ArticleBody-googlePreferredSourceContainer\" data-module=\"GooglePreferredSource\" data-id=\"RegularArticle-GooglePreferredSource-5\"><a href=\"https:\/\/www.google.com\/preferences\/source?q=https:\/\/www.cnbc.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Choose CNBC as your preferred source on Google and never miss a moment from the most trusted name in business news.<\/a><\/div>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.cnbc.com\/2026\/03\/27\/astrazeneca-stock-az-trial-lung-drug-shares-tozorakimab.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AstraZeneca&#8216;s stock rose over 3% after Britain&#8217;s most valuable company said its experimental lung disease medicine met its target in two late-stage clinical trials. The respiratory treatment tozorakimab, reduced flare-ups of chronic obstructive pulmonary disease (COPD) in both former smokers and in the overall population versus placebo, the company said. &#8220;This marks a notable shift&#8230;<\/p>\n<p class=\"more-link-wrap\"><a href=\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\" class=\"more-link\">Read More<span class=\"screen-reader-text\"> &ldquo;AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed&rdquo;<\/span> &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":5207,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/image.cnbcfm.com\/api\/v1\/image\/108198691-1757936194403-gettyimages-2221649488-Astrazeneca_Office_Building_in_Shanghai.jpeg?v=1760116750&w=1920&h=1080","fifu_image_alt":"","footnotes":""},"categories":[4],"tags":[420,927,77,4098,70,4101,3999,928,156,3018,702,419,4099,4100],"class_list":["post-5206","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-astrazeneca-plc","tag-breaking-news-markets","tag-business-news","tag-ftse-100","tag-health-care-industry","tag-ishares-msci-united-kingdom-etf","tag-ishares-u-s-pharmaceuticals-etf","tag-markets","tag-pharmaceuticals","tag-regeneron-pharmaceuticals-inc","tag-roche-holding-ag","tag-sanofi-sa","tag-spdr-sp-pharmaceuticals-etf","tag-vanguard-ftse-europe-index-fund-etf-shares"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v17.8 (Yoast SEO v22.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed - Breaking News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed\" \/>\n<meta property=\"og:description\" content=\"AstraZeneca&#8216;s stock rose over 3% after Britain&#8217;s most valuable company said its experimental lung disease medicine met its target in two late-stage clinical trials. The respiratory treatment tozorakimab, reduced flare-ups of chronic obstructive pulmonary disease (COPD) in both former smokers and in the overall population versus placebo, the company said. &#8220;This marks a notable shift...Read More &ldquo;AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed&rdquo; &raquo;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\" \/>\n<meta property=\"og:site_name\" content=\"Breaking News\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-27T16:47:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/image.cnbcfm.com\/api\/v1\/image\/108198691-1757936194403-gettyimages-2221649488-Astrazeneca_Office_Building_in_Shanghai.jpeg?v=1760116750&w=1920&h=1080\" \/>\n<meta name=\"author\" content=\"Admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/image.cnbcfm.com\/api\/v1\/image\/108198691-1757936194403-gettyimages-2221649488-Astrazeneca_Office_Building_in_Shanghai.jpeg?v=1760116750&w=1920&h=1080\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\"},\"author\":{\"name\":\"Admin\",\"@id\":\"https:\/\/ventil.rs\/blog\/#\/schema\/person\/8b364f5cc7fbc8705a888e63db8c026a\"},\"headline\":\"AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed\",\"datePublished\":\"2026-03-27T16:47:44+00:00\",\"dateModified\":\"2026-03-27T16:47:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\"},\"wordCount\":519,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ventil.rs\/blog\/#organization\"},\"keywords\":[\"AstraZeneca PLC\",\"Breaking News: Markets\",\"business news\",\"FTSE 100\",\"Health care industry\",\"iShares MSCI United Kingdom ETF\",\"iShares U.S. Pharmaceuticals ETF\",\"Markets\",\"Pharmaceuticals\",\"Regeneron Pharmaceuticals Inc\",\"Roche Holding AG\",\"Sanofi SA\",\"Spdr S&amp;P Pharmaceuticals Etf\",\"Vanguard FTSE Europe Index Fund ETF Shares\"],\"articleSection\":[\"Health\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/#respond\"]}],\"copyrightYear\":\"2026\",\"copyrightHolder\":{\"@id\":\"https:\/\/ventil.rs\/blog\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\",\"url\":\"https:\/\/ventil.rs\/blog\/health\/astrazeneca-stock-jumps-after-surprise-trial-win-for-lung-disease-drug-where-rivals-have-failed\/\",\"name\":\"AstraZeneca stock jumps after surprise trial win for lung disease drug where rivals have failed - 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